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Immunometabolic control by Klebsiella pneumoniae

Immunometabolic control by Klebsiella pneumoniae

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DOI	10.1097/IN9.0000000000000028
刊名	Immunometabolism IJ
年，卷(期)	2023, 5(3)
作者	Prince, Alice; Wong Fok Lung, Tania,
作者单位	[Prince, Alice; Wong Fok Lung, Tania] Columbia Univ, Dept Pediat, New York, NY 10027 USA
摘要	Klebsiella pneumoniae is a common Gram-negative pathogen associated with community-acquired and healthcare-associated infections. Its ability to acquire genetic elements resulted in its rapid development of resistance to virtually all antimicrobial agents. Once infection is established, K. pneumoniae is able to evade the host immune response and perhaps more importantly, undergo metabolic rewiring to optimize its ability to maintain infection. K. pneumoniae lipopolysaccharide and capsular polysaccharide are central factors in the induction and evasion of immune clearance. Less well understood is the importance of immunometabolism, the intersection between cellular metabolism and immune function, in the host response to K. pneumoniae infection. Bacterial metabolism itself is perceived as a metabolic stress to the host, altering the microenvironment at the site of infection. In this review, we will discuss the metabolic responses induced by K. pneumoniae, particularly in response to stimulation with the metabolically active bacteria versus pathogen-associated molecular patterns alone, and their implications in shaping the nature of the immune response and the infection outcome. A better understanding of the immunometabolic response to K. pneumoniae may help identify new targets for therapeutic intervention in the treatment of multidrug-resistant bacterial infections.
Abstract	Klebsiella pneumoniae is a common Gram-negative pathogen associated with community-acquired and healthcare-associated infections. Its ability to acquire genetic elements resulted in its rapid development of resistance to virtually all antimicrobial agents. Once infection is established, K. pneumoniae is able to evade the host immune response and perhaps more importantly, undergo metabolic rewiring to optimize its ability to maintain infection. K. pneumoniae lipopolysaccharide and capsular polysaccharide are central factors in the induction and evasion of immune clearance. Less well understood is the importance of immunometabolism, the intersection between cellular metabolism and immune function, in the host response to K. pneumoniae infection. Bacterial metabolism itself is perceived as a metabolic stress to the host, altering the microenvironment at the site of infection. In this review, we will discuss the metabolic responses induced by K. pneumoniae, particularly in response to stimulation with the metabolically active bacteria versus pathogen-associated molecular patterns alone, and their implications in shaping the nature of the immune response and the infection outcome. A better understanding of the immunometabolic response to K. pneumoniae may help identify new targets for therapeutic intervention in the treatment of multidrug-resistant bacterial infections.
关键词	immunometabolism; metabolic reprogramming; Klebsiella pneumoniae; antimicrobial resistance; pulmonary infection; tolerance; resistance
KeyWord	immunometabolism; metabolic reprogramming; Klebsiella pneumoniae; antimicrobial resistance; pulmonary infection; tolerance; resistance
基金项目
页码	1-9

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引用本文

Prince, Alice; Wong Fok Lung, Tania. Immunometabolic control by Klebsiella pneumoniae [J]. Immunometabolism. 2023; 5; (3). 1 - 9.

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