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Oxidative stress in gut TH17 cells makes mice susceptible to bacterial infection

Oxidative stress in gut TH17 cells makes mice susceptible to bacterial infection

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DOI	10.1097/IN9.0000000000000049
刊名	Immunometabolism IJ
年，卷(期)	2024, 6(4)
作者	O'Shaughnessy, Simon; Finlay, David K.,
作者单位	[O'Shaughnessy, Simon; Finlay, David K.] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci, Dublin, Ireland; [Finlay, David K.] Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Trinity Biomed Sci, Dublin, Ireland
摘要	A recent paper published in Cell Metabolism in August 2024 by Dirk Brenner's laboratory highlights the importance of effectively managing reactive oxygen species (ROS) in gut T(H)17T cells for minimizing the damage caused by intestinal bacterial infection. This commentary will discuss the control of cellular ROS by glutathione and the emerging understanding that neutralizing ROS in immune cells is essential for the individualized functions of different immune subsets. In the case of this study, managing ROS within T(H)17 cells in the gut was shown to be essential to sustain the production of IL22 cytokine to maintain gut homeostasis in response to bacterial infection.
Abstract	A recent paper published in Cell Metabolism in August 2024 by Dirk Brenner's laboratory highlights the importance of effectively managing reactive oxygen species (ROS) in gut T(H)17T cells for minimizing the damage caused by intestinal bacterial infection. This commentary will discuss the control of cellular ROS by glutathione and the emerging understanding that neutralizing ROS in immune cells is essential for the individualized functions of different immune subsets. In the case of this study, managing ROS within T(H)17 cells in the gut was shown to be essential to sustain the production of IL22 cytokine to maintain gut homeostasis in response to bacterial infection.
关键词	T(H)17; CD4; IL22; IL17; mitochondria, reactive oxygen species; mTORc1; gastrointestinal infection with Citrobacter rodentium; glutathione; glutamate-cysteine ligase catalytic subunit; mitochondrial transcription factor A
KeyWord	T(H)17; CD4; IL22; IL17; mitochondria, reactive oxygen species; mTORc1; gastrointestinal infection with Citrobacter rodentium; glutathione; glutamate-cysteine ligase catalytic subunit; mitochondrial transcription factor A
基金项目
页码	1-4

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引用本文

O'Shaughnessy, Simon; Finlay, David K.. Oxidative stress in gut TH17 cells makes mice susceptible to bacterial infection [J]. Immunometabolism. 2024; 6; (4). 1 - 4.

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