Targeting Nuclear Receptors for TH17-Mediated Inflammation: REV-ERBerations of Circadian Rhythm and Metabolism-Immunometabolism-CSCIED科技核心评价数据库-手机版

Targeting Nuclear Receptors for TH17-Mediated Inflammation: REV-ERBerations of Circadian Rhythm and Metabolism

Targeting Nuclear Receptors for TH17-Mediated Inflammation: REV-ERBerations of Circadian Rhythm and Metabolism

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DOI	10.20900/immunometab20220006
刊名	Immunometabolism IJ
年，卷(期)	2022, 4(2)
作者	Mosure, Sarah A.; Wilson, Adrianna N.; Solt, Laura A.,
作者单位	[Mosure, Sarah A.; Wilson, Adrianna N.; Solt, Laura A.] Scripps Res Inst, Dept Immunol & Microbiol, Jupiter, FL 33458 USA; [Mosure, Sarah A.; Wilson, Adrianna N.] Scripps Res Inst, Skaggs Grad Sch Chem & Biol Sci, Jupiter, FL 33458 USA; [Mosure, Sarah A.]
摘要	Since their discovery, a significant amount of progress has been made understanding T helper 17 (T(H)17) cells' roles in immune homeostasis and disease. Outside of classical cytokine signaling, environmental and cellular intrinsic factors, including metabolism, have proven to be critical for non-pathogenic vs pathogenic T(H)17 cell development, clearance of infections, and disease. The nuclear receptor ROR gamma t has been identified as a key regulator of T(H)17-mediated inflammation. Nuclear receptors regulate a variety of physiological processes, ranging from reproduction to the circadian rhythm, immunity to metabolism. Outside of ROR gamma t, the roles of other nuclear receptors in T(H)17-mediated immunity are not as well established. In this mini-review we describe recent studies that revealed a role for a different member of the nuclear receptor superfamily, REV-ERB alpha, in the regulation of T(H)17 cells and autoimmunity. We highlight similarities and differences between reports, potential roles beyond T(H)17-mediated cytokine regulation, unresolved questions in the field, as well as the translational potential of targeting REV-ERB alpha.
Abstract	Since their discovery, a significant amount of progress has been made understanding T helper 17 (T(H)17) cells' roles in immune homeostasis and disease. Outside of classical cytokine signaling, environmental and cellular intrinsic factors, including metabolism, have proven to be critical for non-pathogenic vs pathogenic T(H)17 cell development, clearance of infections, and disease. The nuclear receptor ROR gamma t has been identified as a key regulator of T(H)17-mediated inflammation. Nuclear receptors regulate a variety of physiological processes, ranging from reproduction to the circadian rhythm, immunity to metabolism. Outside of ROR gamma t, the roles of other nuclear receptors in T(H)17-mediated immunity are not as well established. In this mini-review we describe recent studies that revealed a role for a different member of the nuclear receptor superfamily, REV-ERB alpha, in the regulation of T(H)17 cells and autoimmunity. We highlight similarities and differences between reports, potential roles beyond T(H)17-mediated cytokine regulation, unresolved questions in the field, as well as the translational potential of targeting REV-ERB alpha.
关键词	T(H)17 cell; nuclear receptor; ROR gamma t; REV-ERB; T regulatory; inflammation; metabolism
KeyWord	T(H)17 cell; nuclear receptor; ROR gamma t; REV-ERB; T regulatory; inflammation; metabolism
基金项目
页码	1-12

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Mosure, Sarah A.; Wilson, Adrianna N.; Solt, Laura A.. Targeting Nuclear Receptors for TH17-Mediated Inflammation: REV-ERBerations of Circadian Rhythm and Metabolism [J]. Immunometabolism. 2022; 4; (2). 1 - 12.

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