Journal of International Psychiatry

【Abstract】 Objective This study aims to investigate the efficacy and safety of agomelatine combined with eperisone in the treatment of chronic tension-type headache (CTTH) in youth. Methods 80 youth individuals with CTTH were divided into two groups according to whether on shift or not: the control group was treated with eperisone, the treatment group was treated with argonaut on the basis of the control treatment. Both of the two groups were evaluated by Pittsburgh sleep rating scale (PSQI) before treatment. The treatments was lasted for 6weeks, then the clinical efficacy and adverse reactions was compared. Results There were significantly higher PSQI factors scores of the patients with shift work than those with non-shift work, including the total score of PSQI、sleep quality、time to fall asleep、hypnotic drugs and sleep disorder factor scores. There was a better therapeutic effect of the treatment group, with statistical significance (P<0.05). Within the treatment group, the efficacy of shift patients was better than that of non-shift patients (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Agomelatine is effective and safe in the treatment of chronic tension headache. Agomelatine had a significant effect on CTTH patients in the shift group.

【Key words】Agomelatine; Eperisone; PSQI ; Shift work