| Abstract |
[Abstract] 【Objective】 To investigate the relationship between serum levels of transcription factors Forkhead box protein O1 (FOXO1), interleukin-6 (IL-6), C-reactive protein (CRP), homocysteine (Hcy), and depression in elderly patients with chronic heart failure (CHF). 【Methods】 Sixty elderly patients with CHF and depression admitted to our hospital from January 2020 to January 2022 were selected as the combined group, and another 40 elderly CHF patients were selected as the non combined group. Detect and compare the serum levels of FOXO1, IL-6, CRP, and Hcy between two groups, and compare the baseline data of elderly CHF patients with different levels of depression [gender, age, New York Heart Association (NYHA) cardiac function grading] and serum levels of FOXO1, IL-6, CRP, and Hcy. Finally, the correlation between serum levels of FOXO1, IL-6, CRP, and Hcy in elderly CHF patients and the degree of depression was analyzed through Spearman rank correlation analysis.【Results】 The serum levels of FOXO1, IL-6, CRP, and Hcy in the combined group were higher than those in the control group, and the difference was statistically significant (P<0.05); The comparison of serum FOXO1, IL-6, CRP, and Hcy levels showed that the mild group was less than the moderate group and less than the severe group, and the difference was statistically significant (P<0.05); The serum levels of FOXO1, IL-6, CRP, and Hcy are positively correlated with the degree of depression in elderly CHF patients, and P<0.05. 【Conclusion】 The serum levels of FOXO1, IL-6, CRP, and Hcy are positively correlated with the degree of depression in elderly CHF patients. Clinicians should closely monitor these indicators to predict the occurrence and development of depression.
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