| Abstract |
【Abstract】 Objective: To compare and analyze the effects of aripiprazole and tiapride on the efficacy, T lymphocyte subsets and neurotransmitters of children with tic disorder. Methods: 76 children with tic disorders who were admitted to our hospital from September 2020 to September 2022 were selected as the study subjects. They were divided into Aripiprazole (38 cases) and Tiapride (38 cases) according to the method of random number table. Tiapride was treated with Tiapride hydrochloride tablets and Aripiprazole was treated with Aripiprazole tablets. Compare the clinical treatment effect of the two groups of children, and analyze the differences in the levels of T lymphocyte subsets (CD3+, CD3+CD4+, CD4+/CD8+) and neurotransmitters [dopamine (DA), norepinephrine (NE), 5-hydroxytryptamine (5-HT)] before and after treatment. The occurrence probability of adverse reactions such as drowsiness, dizziness, nausea, insomnia and exertion during the treatment was recorded. Results: The total effective rate of Tipiride group was 81.6% (31/38), and the total effective rate of aripiprazole was 97.4% (37/38). Compared with Tipiride group, the total effective rate of aripiprazole group was higher (P<0.05). Before treatment, there was no significant difference in the values of CD3+, CD3+CD4+and CD4+/CD8+between the two groups. After treatment, the values of CD3+, CD3+CD4+and CD4+/CD8+increased in both groups, and the increase was more significant in aripiprazole group (P<0.05). Before treatment, there was no significant difference in the levels of DA, NE and 5-HT between the two groups. After treatment, the levels of DA, NE and 5-HT in the two groups decreased, and the decrease in aripiprazole group was more significant (P<0.05). A total of 2 children in the aripiprazole group had adverse reactions to treatment, with an incidence of 5.3% (2/38), and 8 children in the thiopiride group had adverse reactions to treatment, with an incidence of 21.1% (8/38). Compared with the thiopiride group, the total incidence of adverse reactions in the aripiprazole group was lower (P<0.05).Conclusion:Both aripiprazole and tiapride have good efficacy in the treatment of tic disorders, but aripiprazole has better improvement in T-lymphocyte subsets and neurotransmitters, and higher safety.
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