Journal of International Psychiatry

【Abstract】 Objective To explore the relationship between serum inflammatory factors and monoamine neurotransmitter levels in elderly patients with hypertension combined with anxiety and depression. Methods 90 elderly patients with hypertension combined with anxiety and depression admitted to our hospital from January 2022 to December 2023 were selected as the combined group, and another 60 elderly patients with hypertension during the same period were selected as the non combined group. Compare two groups of Self Rating Anxiety Scale (SAS) and Self Rating Depression Scale (SDS), and measure serum levels of inflammatory factors [tumor necrosis factor] in both groups-α Tumor Necrosis Factor-α， TNF-α）、 Interleukin-6 (IL-6), interleukin-1β (nterleukin-1)β， IL-1β）] And the levels of monoamine neurotransmitters [5-hydroxytryptamine (5-HT), dopamine (DA), norepinephrine (NE)] were analyzed using Spearman rank correlation to investigate the correlation between serum inflammatory factors, monoamine neurotransmitter levels, and SAS and SDS scores in elderly hypertensive patients with anxiety and depression. Results The SAS and SDS scores of the merged group were higher than those of the non merged group (P<0.05); Merge group serum TNF-α、 IL-6, IL-1β The level was higher than that of the unmerged group (P<0.05); The levels of DA, NE, and 5-HT in the combined group were lower than those in the non combined group (P<0.05); Serum TNF levels in elderly hypertensive patients with anxiety and depression-α、 IL-6, IL-1β The level is positively correlated with SAS and SDS scores, and negatively correlated with DA, NE, and 5-HT levels. Conclusion Elderly patients with hypertension combined with anxiety and depression are closely related to serum inflammatory factors and monoamine neurotransmitter levels, and clinical attention should be paid closely.

【Key words】 Hypertension; Anxiety; Depression; Inflammatory factors; Monoamine neurotransmitters