| Abstract |
[Abstract]: Objective Understanding the impact of maternal childhood trauma on childhood trauma and anxiety in adolescents with depression and on the brain mechanisms of their offspring Methods A total of 106 subjects were included in this study, and the Childhood Trauma Questionnaire, Clan Anxiety Scale, Clan Depression Scale, Depressive Symptom Screening Scale, and Generalized Anxiety Disorder Scale were used to evaluate hospitalized adolescents with depressive episodes and healthy groups. Adolescents and their mothers were investigated, and four amygdala subregions (left and right lateral and left and right inner) were selected as regions of interest to compare the whole-brain resting-state functional connectivity of offspring of mothers with and without childhood trauma. Results (1) The physical neglect scores, emotional abuse scores, emotional neglect scores, anxiety and depression scores of mothers in the depressive episode group were significantly higher than those of mothers in the healthy group, with statistical differences (p < 0.05); (2) Among adolescents with depressive episodes, , there was no statistical difference in offspring anxiety scores, childhood trauma factor scores and total scores between the group whose mothers suffered childhood trauma and the group whose mothers did not suffer childhood trauma (p > 0.05); (3) among adolescents with depressive episodes, those who suffered childhood trauma Compared with mothers who had not suffered childhood trauma, the functional connectivity values of the amygdala as the area of interest and the right parahippocampal gyrus, right lingual gyrus, left inferior occipital gyrus, right superior frontal gyrus and other brain areas were reduced. Conclusion Maternal childhood trauma and anxiety and depression may increase the risk of depression in offspring, and maternal childhood trauma affects the brain functional network of offspring with the amygdala as the seed point, but maternal childhood trauma does not affect anxiety symptoms and childhood trauma in adolescents with depression.
|