Journal of International Psychiatry

Objective: To study the effects of paroxetine on emotional state, cognitive function, and quality of life in patients with intracranial infection and anxiety and depression. Method: 90 patients with intracranial infection accompanied by anxiety and depression in the neurosurgery department of our hospital from June 2020 to June 2022 were randomly divided into two groups. The control group (45 cases) received routine treatment, and the observation group (45 cases) received paroxetine combined treatment. The emotional status, cognitive function, quality of life, and adverse reactions of the two groups of patients were compared. Result: After treatment, the Hamilton Anxiety Scale and Hamilton Depression Scale scores in the observation group were lower than those in the control group (P<0.05); After treatment, the neurological deficit score in the observation group was lower than that in the control group, and the score on the Montreal Cognitive Function Assessment Scale was higher than that in the control group (P<0.05); After treatment, the scores of material function, social function, psychological function, and physical function in the observation group were higher than those in the control group (P<0.05); There was no statistically significant difference in the total incidence of adverse reactions between the two groups of patients (P>0.05). Conclusion: Combined treatment with paroxetine can effectively improve the emotional state of patients with intracranial infection and anxiety and depression, promote cognitive function recovery, improve quality of life, and have high safety.

【 Keywords 】 Intracranial infection; Paroxetine; Emotional state; cognitive function