Journal of International Psychiatry

【Abstract】Objective To explore the correlation of working memory and cognitive function between nonorganic insomnia (NI) patients and health controls (HC). Methods A total of 50 NI patients were compared with matched 50 HC. Working memory of all the subjects were assessed by N-back test；Cognitive function of all the subjects were assessed by verbal fluency、digital symbol substitution、Trail Making Test、Stroop color word testing，Comparison the correlation between working memory and cognitive function in NI group. Results The reaction time of 2-back and 3-back test in NI group[(1520.18±110.23)ms；(2255.15±409.88)ms] were higher than HC group[(1376.10±165.91)ms；(1873.39±208.07)ms] (All, P˂0.05). Compared with HC group[(12.68±3.16)s，(38.36±5.23)score，(99.68±22.04)s，(5.28±1.38)s]，NI group [(11.44±2.73)s，(35.40±6.63)score，(109.14±24.56)s，(9.56±1.31)s]showed significantly impaired in performance of verbal fluency、digital symbol substitution、Trail Making Test-B、anti-interference reaction time of Stroop task(All, P˂0.05)，The reaction time of 3-back test in NI group was negatively correlated with Digital symbol substitution in NI group(r=—0.363，P=0.010)，but positively correlated with Trail Making Test-A and B(r=0.379，P=0.007；r=0.314，P=0.027). Conclusion The studies find working memory and cognitive function in early NI was impaired，and cognitive function impairment is closely related to working memory.

Insomnia；memory；cognitive