| Abstract |
[Objective] To observe the clinical efficacy and safety of Huoxue Huayu Recipe combined with Aripiprazole in the treatment of schizophrenia with metabolic syndrome. Methods From June 2020 to June 2022, 60 schizophrenic patients with metabolic syndrome who were hospitalized in our hospital were randomly divided into the treatment group and the control group, with 30 cases in each group, The treatment group was treated with Aripiprazole combined with Huoxue Huayu Recipe, and the control group was treated with Aripiprazole for three months. Glucose test Fasting blood sugar, blood lipid level, Hemorheology indicators (including whole blood low shear, high shear, and reduced viscosity), the total score of the Brief Psychiatric Rating Scale (BPRS), the total score of the Positive and Negative Syndrome Scale (PANSS), the body mass index (BMI), and the safety of the patients in the two groups were measured at baseline, 4 weeks after treatment, 8 weeks after treatment, and 12 weeks after treatment. Results ① There were no significant differences in baseline BMI, fasting blood glucose, triglycerides and HDL-C, high shear blood viscosity, low shear blood viscosity, and plasma viscosity between the two groups of patients. The treatment group showed significant reductions in all indicators at 4, 8, and 12 weeks after treatment, while the control group showed no significant changes. The treatment group was lower than the control group at different time points (all P<0.05) There was no significant difference in BMI, BPRS total score, and PANSS total score between the two groups of patients at baseline. The treatment group and control group showed significant reductions in all indicators above 4, 8, and 12 weeks after treatment (all P<0.05), and the treatment group was lower than the control group at different time points (all P<0.05) The incidence of adverse reactions in the treatment group and control group was 20% and 16.67% respectively, and there was no significant difference in the incidence of adverse reactions between the two groups of patients(χ2=0.111, P=0.739).Conclusion Huoxue Huayu Recipe combined with Aripiprazole has clear clinical efficacy and good safety in the treatment of schizophrenia with metabolic syndrome, which is worthy of further clinical promotion.
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