Journal of International Psychiatry

[Abstract] Objective To investigate the effect of pramipexole hydrochloride on the emotional status as well as cognitive function of Parkinsons patients. Methods Eighty-five patients with Parkinsons disease from January 2021 to December 2022 were selected in this study, and divided into two groups by simple randomization method. The control group was treated with levodopa, and the observation group was treated with pramipexole hydrochloride in combination with the control group. The Simple Mental State Examination (MMSE), Parkinsons Disease Rating Scale (UPDRS) Hamilton Depression as well as Anxiety Scale (HAMD), (HAMA) were compared before and after treatment. Results MMSE scores increased and UPDRS scores decreased after treatment in both groups, and MMSE scores were significantly higher and UPDRS scores were significantly lower in the observation group than in the control group after treatment (P<0.05). The HAMD scores as well as HAMA scores were significantly lower in both groups after treatment, and both scores were significantly lower in the observation group than in the control group after treatment (P<0.05). Conclusion Pramipexole hydrochloride can effectively relieve anxiety and depression in Parkinsons disease, enhance cognitive function, and promote the improvement of clinical symptoms of Parkinsons disease.

Key words Pramipexole Hydrochloride; Parkinson’s Disease; Emotional Status; Cognitive Function