| Abstract |
【Abstract】Objective: To analyze the expression and significance of serum chemokine 2 (CCL2), macrophage migration inhibitor (MIF) and oxidative stress index in patients with schizophrenia. Methods: A total of 106 patients with schizophrenia who received medical treatment in our hospital from February 2020 to February 2023 were selected as the observation group, and 106 healthy patients who underwent physical examination in our hospital during the same period were selected as the healthy group. Serum levels of CCL2, MIF and oxidative stress indexes [superoxide dismutase (SOD) and malondialdehyde (MDA)] of the two groups were detected and compared. Cognitive function was assessed by schizophrenia cognitive function Kit test (MCCB), and MCCB scores were compared between the two groups. 106 patients with schizophrenia were divided into 2 groups according to whether they had cognitive impairment. 60 patients with cognitive impairment were set as the observation group, and 46 patients without cognitive impairment were set as the observation group. Serum levels of CCL2, MIF and oxidative stress indexes were compared between the two groups. Pearson was used to analyze the correlation between serum CCL2, MIF levels, oxidative stress indexes and MCCB scores, and ROC curve was used to analyze the predictive value of serum CCL2, MIF and oxidative stress indexes on cognitive dysfunction. Results: The serum levels of CCL2, MIF and MDA in the observation group were higher than those in the healthy group, P < 0.05, and the serum level of SOD in the observation group was lower than that in the healthy group, P < 0.05. Social cognition, reasoning and problem solving ability, visual learning, word learning, working memory, attention/alertness, information processing speed score and total score of MMCB in observation group were lower than those in healthy group (P < 0.05). The serum levels of CCL2, MIF and MDA in observation group 1 were higher than those in observation group 2 (P < 0.05), and the serum level of SOD in observation group 1 was lower than that in observation group 2 (P < 0.05). Serum CCL2, MIF and MDA were negatively correlated with MCCB score, P < 0.05 (r =-0.394, -0.411, -0.386), and serum SOD was positively correlated with MCCB score, P < 0.05 (r =0.403). The AUC of the combined detection of serum CCL2, MIF, SOD and MDA was 0.918, and the 95%CI was 0.785-0.952. The sensitivity (94.64%) and specificity (90.67%) were higher than that of single detection (76.02%, 72.71%), (75.13%, 71.16%), (72.26%, 69.34%), (74.03%, 70.98%), P < 0.05. Conclusion: Abnormal expression of CCL2, MIF, SOD and MDA in serum is involved in the occurrence and development of schizophrenia, which is closely related to the cognitive function of patients. Combined detection of these cytokines can improve the sensitivity and specificity of the prediction of cognitive dysfunction, which has certain reference value.
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