| Abstract |
Abstract Objective: To observe the effects of ziprasidone combined with modified electroconvulsive therapy (modified electroconvulsive therapy, MECT) on therapeutic effect, aggressive behavior, and cognitive function in patients with schizophrenia. Methods: One hundred patients with schizophrenia admitted to the hospital from January 2021 to February 2022 were selected and randomly divided into the observation group and the control group, with 50 cases in each group. The control group was treated with ziprasidone, and the observation group was treated with MECT on this basis. The two groups were compared on the rapeutic effects, Modified Overt Aggression Scale (modified overt aggression scale, MOAS) scores, Positive and Negative Syndrome Scale (positive and negative symptom scale，PANSS) score, Montreal Cognitive Assessment Scale (Montreal cognitive assessment, MoCA) scores, and Mini Mental State Examination Scale (mini-mental state examination, MMSE) scores , serum inflammatory factors, and glucose and lipid metabolism. Results: The total effective rate of the observation group (92.00%) was higher than that of the control group (76.00%) (P<0.05). After 4 weeks of treatment, MOAS score, PANSS score, serum high-sensitivity C-reactive protein, interleukin-6 and tumor necrosis factor-α levels of the observation group were lower than those of the control group (P<0.05). MoCA score and MMSE score were higher than those of the control group (P<0.05). There was no significant difference in the levels of fasting blood glucose, triglycerides, total cholesterol, low-density lipoprotein, and high-density lipoprotein in the two groups before and after treatment (P>0.05). The incidence rates of adverse reactions in the two groups were comparable (P>0.05). Conclusion: Ziprasidone combined with MECT is effective in the treatment of schizophrenia, which helps to improve the patients’ symptoms, aggressive behavior and cognitive function, and relieve inflammatory response, with little influence on glucose and lipid metabolism and high safety.
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