Journal of International Psychiatry

Objective: To explore the correlation between physiological indexes such as hypersensitive C-reactive protein and non-suicidal self-injury (NSSI) behavior of adolescents with mental disorders. Methods: The adolescent patients with mental disorders in the Third Peoples Hospital of Zhongshan City from May 2021 to April 2022 were retrospectively analyzed, and the patients were divided into NSSI group and non-NSSI group according to whether they were accompanied by NSSI behavior. The propensity score matching (PSM) was used in 1:1 matching between two groups, and the differences of hypersensitive C-reactive protein, neutrophil-to-lymphocyte ratio and cholesterol level between the two groups after PSM matching were compared, and the predictive efficacy of different physiological parameters for NSSI behavior were compared. Results: A total of 150 patients were analyzed retrospectively, 93 of whom were diagnosed as NSSI. There were 37 subjects in both groups after PSM. There was no statistical difference in parameters of social demography and psychology between the two groups after PSM. The neutrophil-to-lymphocyte ratio and hypersensitive C-reactive protein in NSSI group were significantly higher than those in non-NSSI group (P < 0.05). The level of peripheral blood cholesterol in NSSI group was significantly lower than that in non-NSSI group (P=0.008). Among them, hs-CRP has the largest area under the curve (AUC=0.891) and the best prediction efficiency. Conclusions: Physiological indexes such as hypersensitive C-reactive protein, cholesterol and neutrophil-to-lymphocyte ratio are significantly correlated with the occurrence of non-suicidal self-injury behavior in adolescents with mental disorders, among which hypersensitive C-reactive protein has the best predictive efficacy of NSSI behavior. Those provides scientific backing for early identification and early intervention of NSSI behavior.

Non-suicidal self-injury；Adolescence; Mental disorders; Inflammation