Journal of International Psychiatry

[Abstract] Objective To investigate the clinical effect of sertraline on coronary heart disease complicated with depression. Methods Eighty-six patients with coronary heart disease combined with depression in the Seventh Peoples Hospital of Hebei Province from April 2020 to October 2022 were the subjects of this study, and were randomly divided into two groups by the number table method. The control group was given conventional cardiology treatment as well as psychological intervention, and the observation group was given sertraline treatment therapy on the basis of the control group. The Hamilton anxiety and depression scores (HAMA), (HAMD), heart rate variability (HRV), left ventricular ejection fraction (LVEF) and the incidence of cardiovascular adverse events were compared between the two groups of patients before and after treatment. Results The HAMA score and HAMD score were significantly lower in both groups after treatment, and both scores were significantly lower in the observation group than in the control group after treatment (P<0.05). The standard deviation of normal sinus R-R interval (SDNN), high frequency power (HF) and left ventricular ejection fraction (LVEF) increased and low frequency power (LF) decreased in both groups after treatment, and all indexes were better in the observation group than in the control group after treatment (P<0.05). The incidence of cardiovascular adverse events in the observation group was significantly lower than that in the control group (P<0.05). Conclusion Sertraline for coronary heart disease combined with depression is effective in reducing negative emotions, improving autonomic function as well as cardiac function, and reducing the incidence of adverse cardiovascular events.

Key words Sertraline; Comorbid Depression; Coronary Artery Disease; Autonomic Function; Cardiac Function; Adverse Cardiovascular Events