Journal of International Psychiatry

[Abstract] Objective: To study the effects of sertraline on depressive state and neurological function in patients with cerebral hemorrhage complicated with depression. Methods: A total of 90 patients with cerebral hemorrhage complicated with depression from February 2021 to February 2023 in our hospital were randomly assigned. Both groups received routine treatment for cerebral hemorrhage, 45 patients in the control group received routine psychological counseling, and 45 patients in the observation group received combined treatment with sertraline. Depressed mood, neurological function, related factor levels and adverse reactions were compared between the two groups. Results: After treatment, the score of Hamilton Depression Scale (HAMD) in observation group was lower than that in control group (P < 0.05). After treatment, the neurological deficit score (NIHSS) in observation group was lower than that in control group, and Barthel index (BI) was higher than that in control group (P < 0.05). After treatment, the levels of serum neurofilament light chain protein (NfL) and phosphorylated tau protein 181 (P-TAU181) in observation group were lower than those in control group (p < 0.05). No obvious adverse reactions occurred in both groups. Conclusion: Sertraline can effectively improve the depressive state of patients with cerebral hemorrhage complicated with depression, and promote the recovery of neurological function in patients with high safety, and has clinical popularization value.

【 Key words 】 Cerebral hemorrhage; Depression; Sertraline; psychological counseling