Journal of International Psychiatry

Objective: To explore relationship between levels of non-enzymatic antioxidants and aggressive behavior in patients with acute schizophrenia. Methods: A total of 112 patients with acute schizophrenia were enrolled, including 77 patients in non-aggressive group and 85 patients in aggressive group. General social data of patients were collected by self-made questionnaire, clinical symptoms were assessed by the Positive and Negative Symptom Scale, aggressive behavior were assessed by the Modified Overt Aggression Scale, and non-enzymatic antioxidants levels were detected by fully automated biochemical analyzer. The relationship between levels of non-enzymatic antioxidants and aggressive behavior were statistically analyzed. Results: The positive symptom score in the aggressive group was higher than that in the non-aggressive group (P＜0.05), while the levels of total bilirubin (TBIL), direct bilirubin, and indirect bilirubin in the aggressive group were higher than those in the non-aggressive group (P＜0.05). Gender, use clozapine, TBIL, and positive symptom score are the influencing factors of aggressive behavior in patients with acute schizophrenia, and high TBIL level having the most significant impact (OR＝1.275，P＜0.001). Conclusion: There are some changes in levels of non-enzymatic antioxidants in patients with acute schizophrenia accompanied by aggressive behavior, the difference in bilirubin level is particularly significant, and high TBIL level is a risk factor for aggressive behavior.

schizophrenia;non-enzymatic antioxidants;aggressive behavior