| 摘要 |
摘要 探讨双相情感障碍共病代谢综合征（Metabolic syndrome，MS）的发生情况，分析其危险因素，以及代谢综合征对认知功能的影响。方法 选取2020年5月至2023年6月期间诊治的106例双相情感障碍患者为研究对象，将共病MS者纳入观察组，未共病MS者纳入对照组，比较两组患者的一般资料，分析共病MS的危险因素，同时比较两组患者的蒙特利尔认知评估量表(Montreal cognitive assessment，MoCA)评分。结果 本研究106例双相情感障碍患者中有40例患者合并代谢综合征，双相情感障碍共病代谢综合征的发生率为37.74%；观察组与对照组在年龄、性别、饮酒史、吸烟史、诊断分型以及心境稳定剂、抗精神病药比较无显著差异（P＞0.05）；与对照组比较，患者糖尿病家族史比例、用药种类指标在观察组更高（χ2=7.799,t=9.704,P均＜0.05）。Logistic回归分析结果显示，患者的糖尿病家族史、用药种类是双相情感障碍共病MS的独立危险因素。观察组的MOCA量表中视空间与执行功能得分及总分均显著低于对照组，差异有统计学意义（t=6.227,3.158，P均＜0.05）。结论 双相情感障碍共病代谢综合征发生率较高，患者的认知功能也更差；糖尿病家族史、用药种类则成为双相情感障碍共病MS的独立危险因素。
|
| Abstract |
Abstract To explore the omorbid metabolic syndrome (MS) in bipolar disorder rate and risk factors, and the impact of metabolic syndrome on cognitive function.Method From May 2020 to June 2023,106 cases of patients with bipolar disorder were selected as the study subjects. Patients with comorbid MS were included into the observation group, while those without comorbid MS were included into the control group. The general information was compared between the two groups, and the risk factors for comorbid MS were analyzed. In the two groups,the MoCA scores were compared.Results Among the 106 patients with bipolar disorder, 40 patients with metabolic syndrome, and rate was 37.74%; Between the observation group and the control group ,there was of no statistically significant difference in terms including age, gender, smoking and drinking history, diagnostic typing, mood stabilizers, antipsychotic drugs (P＞0.05); In the observation group compared the control group,the rate of family history of diabetes and the type of medication were significantly higher (χ2=7.799, t=9.704, P＜0.05). Logistic regression analysis showed that family history of diabetes and type of medication were independent risk factors for comorbid metabolic syndrome of bipolar disorder.In the observation group ,visual space and executive function scores in the MOCA scale and total score was significantly lower compared the control group (t=6.227,3.158,P＜0.05). Conclusion The comorbid MS in bipolar disorder rate is higher, and cognitive function is poorer ; Family history of diabetes and type of medication are independent risk factors for comorbidity of bipolar disorder with metabolic syndrome.
|