Journal of International Psychiatry

Objective To investigate the correlation of serum HS-CRP and NLR levels with cognitive function and psychiatric symptoms in patients with schizophrenia. Methods A total of 42 newly hospitalized schizophrenic patients from Shanghai Baoshan Mental Health Center from December 2021 to August 2022 were selected as the case group, while 42 healthy patients with matched basic data were selected as the control group. Participants in both groups were assessed for cognitive function and psychiatric symptoms using the repeatable battery for the assessment of neuropsyehological status（RBANS）、Positive and Negative Symptom Scale (PANSS), and venous blood samples were taken. Serum HS-CRP 、neutrophils and lymphocytes levels in both groups were detected after blood drawing, then calculate the NLR value. Results Compared with normal control group, HS-CRP level and NLR value of case group were increased (HS-CRP: 0.37±0.05ug/dl vs 0.46±0.36ug/dl; NLR:1.67±0.48 vs 2.79±1.01, the difference was statistically significant (P<0.01). Compared with the control group, the total score of cognitive function and each factor score of schizophrenia patients were decreased, and the difference was statistically significant (P<0.05). Analysis of the case group, the expression of HS-CPR level was negatively correlated with the score of immediate memory factor in cognitive function (r=-0.362 P<0.05). There was a positive correlation with the general pathological scale factor score (r=0.369 P<0.05) in the symptom scale; NLR values were negatively correlated with immediate memory factor scores (r=-0.394 P<0.05) and positively correlated with negative symptoms (r=0.39 P<0.05). The PANSS scale and RBANS scale showed a negative correlation between positive and negative symptoms and attention factor in cognitive function (r=-0.521, -0.37 P<0.05), the rest were not correlated. Conclusion The expression level of HS-CRP and NLP in serum of schizophrenic patients were higher than those of normal control group, its were related to the severity of mental symptoms and the decline of cognitive function, mainly reflected in the level of immediate memory and attention disorders, and the more severe symptoms of schizophrenic patients, the worse attention function.

schizophrenia ;hypersensitivity C-reactive protein ; neutrophil to lymphocyte ratio ;cognitive function.