Journal of International Psychiatry

Adolescent depression and circadian rhythm disruption represent two significant health challenges among the global teenage population. Recent scientific research has unveiled intricate mechanisms that underlie the interplay between these two phenomena. This comprehensive review delves into various aspects, meticulously examining the characteristics of circadian rhythm disruption in adolescents with depression, their interactions, potential biological mechanisms, and clinical management strategies. Lastly, we summarize the limitations of existing research and outline future research directions, emphasizing the importance of gaining a profound understanding of this intricate relationship, which may pave the way for novel therapeutic approaches in the future.

Depression; Circadian Rhythm Disruption; Adolescents; Biological Mechanisms; Clinical Management;