Journal of International Psychiatry

[Abstract] Objective: To investigate the effects of different doses of Esperanza Ketamine on sedation, delirium, restlessness and psychological status in patients undergoing radical thyroidectomy for thyroid cancer. Methods: 80 patients who received radical thyroidectomy were randomly divided into two groups. The control group (40 patients) received low-dose Ketamine after anesthesia induction, and the observation group (40 patients) received high-dose Ketamine after anesthesia induction. Result: There was no significant difference in anesthesia time, extubation time, Ramsay sedation score immediately after extubation, and intraoperative remifentanil dosage between the two groups (P>0.05); At 24 hours after surgery, the visual analog scale (VAS) scores in the observation group were significantly lower than those in the control group (P<0.05); Compared 48 hours after surgery, the anxiety and depression scores of the observation group were lower than those of the control group (P<0.05); 48 hours after surgery, the emotional state, psychological support maintenance score, and total score in the observation groups postoperative recovery quality scale-40 (QoR-40) were higher than those in the control group (P<0.05); There was no significant difference in postoperative adverse reactions (P>0.05). Conclusion: Relatively speaking, high-dose Ketamine is more effective in the application of thyroid cancer radical surgery, which can play a better role in analgesia and improving patients negative emotions, and is worth promoting.

[Key words] Espex Ketamine; Radical thyroidectomy for thyroid cancer; Degree of calmness; Psychological state