Journal of International Psychiatry

Objective To explore the abnormalities of brain structure and spontaneous neural activity in adolescents with non-suicidal self-injury, and to find potential objective biological indicators of non-suicidal self-injury. Methods A total of 23 adolescents with non-suicidal self-injury (NSSI group) were included according to the diagnostic criteria of NSSI in DSM-5, and 20 adolescents were matched as healthy control group (HC group). Hamilton Depression Scale, Hamilton Anxiety Scale and Ottawa self-injury inventory were used to evaluate the severity of depression, anxiety and NSSI. The voxel morphology analysis, low frequency ratio of amplitude, low frequency amplitude, local consistency method of modal analysis two groups of youth cerebral gray matter volume and differences of spontaneous neural activity. Results (1) The volume of left dorsolateral superior frontal gyrus and left insular cortex decreased in NSSI group (P < 0.05). (2) In the NSSI group, the ALFF value of the amygdala and the right anterior cingulate gyrus decreased, the ALFF value of the supplementary motor area increased, the fALFF value of the right anterior cingulate gyrus decreased, the ReHo value of the right rectus gyrus decreased, and the ReHo value of the dorsal-lateral superior frontal gyrus increased (P < 0.05).Conclusion Adolescents with NSSI have structural changes in the frontal limbic system and extensive spontaneous neural activity changes, which may be the neurobiological mechanism of NSSI.

Non-suicidal self-injury；Multimodal；Magnetic resonance imaging； Adolescents