长期使用华法林诱导的气管支气管弥漫钙化一例并文献复习-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

长期使用华法林诱导的气管支气管弥漫钙化一例并文献复习

A Case of Long-term Warfarin Induced Diffuse Tracheobronchial Calcification and A Review of The Literature

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DOI	10.12208/j.ijcr.20220012
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2022, 6(1)
作者	杨坚*,赵凯,朱晨,王寿寿,高青,王泽宁,
作者单位	滨州医学院烟台附属医院呼吸与危重症医学科山东烟台 ; 滨州医学院烟台附属医院心血管内科山东烟台 ; 滨州医学院第二临床医学院山东滨州 ; 滨州医学院第一临床医学院山东滨州 ;
摘要	华法林是临床上最常用于预防和治疗血栓栓塞性疾病的一线抗凝药物，最常见的不良反应为出血。儿童心脏瓣膜病术后的气管支气管钙化和长期使用华法林有关，成人心脏瓣膜置换术后、肺栓塞、深静脉血栓和心房颤动等疾病长期使用华法林也可诱导气管支气管钙化。这是华法林一种比较罕见的不良反应，且国内的相关报道罕见。现将滨州医学院烟台附属医院收治的长期使用华法林诱导的气管支气管弥漫钙化病例1例报道如下。
Abstract	Warfarin is the most used first-line anticoagulant for the prevention and treatment of thromboembolic diseases, whose most common adverse reaction is bleeding.Long-term use of warfarin is associated with tracheobronchial calcification after valvular heart disease in children, while long-term use of warfarin in adults can also induce tracheobronchial calcification after heart valve replacement, pulmonary embolism, deep vein thrombosis, and atrial fibrillation.This is a relatively rare adverse reaction of warfarin, and the relevant reports in China are rare.A case of long-term warfarin induced diffuse tracheobronchial calcification admitted to Yantai Affiliated Hospital of Binzhou Medical College is reported as follows.
关键词	华法林；机械瓣置换术；气管支气管钙化；血管钙化
KeyWord	warfarin; mechanical valvereplacement; tracheobronchial calcification; vascular calcification
基金项目
页码	171-175

参考文献
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引用本文

杨坚*,赵凯,朱晨,王寿寿,高青,王泽宁. 长期使用华法林诱导的气管支气管弥漫钙化一例并文献复习 [J]. 国际临床研究杂志. 2022; 6; (1). 171 - 175.

文献评论

赵**新疆维吾****** 已认证✔

2025-11-06 09:32:53

华法林作为一种广泛应用数十年的抗凝药，其常见副作用（如出血）已被熟知，但导致气管支气管钙化是一种极为罕见的并发症。这是一篇具有重要教学和警示意义的优秀病例报告，其首要价值在于报告并警示了这种不寻常的、但具有重要临床意义的副作用，丰富了临床医生对华法林风险谱的认识。

刘**哈尔滨医******

2025-02-01 03:54:08

异位钙化是一种常见的病理现象，但缺乏有效的防治措施。该病例报告启示我们，在临床工作中，应该重视长期服用华法林人群异位钙化的影像与功能的检测，尤其是高剂量儿童开始的女性长期服用者，包括瓣膜病机械瓣置换术后，房颤等。

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