International Journal of Clinical Research

Objective To report a case of MAS syndrome with short stature. Methods The clinic data of MAS syndrome in a child were retrospectively analyzed, the related literatures were reviewed and its clinical features were summarized. Results A girl, four years and nine months old, had growth retardation、precocious puberty、the uterus was enlarged, the right adnexa area was cystic dark area, estrogen and growth hormone were obviously increased, no abnormality was found in the long bone slices of the limbs, and the GNAS gene was positive in the blood samples, had no history of fracture、cafe-au-lait spots, or vaginal bleeding. Conclusions MAS syndrome is a rare and complex syndrome involving multiple systems and organs. The clinical symptoms are varied and the diagnosis and treatment are complicated and challenging. The prognosis of patients with MAS can be improved by fully understanding the lesions of various systems, timely and standardized evaluation and management of the related diseases.

Short stature; Precocious puberty; Ovarian cyst; Syndrome; Literature review