International Medical Research Frontier

Bispecific antibody ( BsAb) is a kind of antibody with two different antigen binding arms. It has the ability to bind two different antigens or two different epitopes of one antigen at the same time. According to whether it contains Fc fragment, it can be divided into IgG-like BsAb and non-IgG-like BsAb. IgG-like BsAb has a longer half-life and is less likely to elicit immune responses against IgG-like BsAb due to its molecular form closer to that of natural antibodies. Non-IgG-like BsAb has a small molecular weight and better tumor permeability because it does not contain the Fc fragment of natural antibody. It can significantly shorten the spacing between specific immune cells and tumor cells and play a more significant tumor killing effect. But the disadvantage is its short half-life. This review provides insight into the molecular structure, mechanism and clinical application of bispecific antibody.

Bispecific antibody; Molecular structure; Antibody preparation; Clinical application