International Journal of Clinical Research

Objective: To study the clinical effect and implementation value of intravitreal injection of anti-VE GF drugs and retinal laser photocoagulation in patients with diabetic retinopathy complicated with macular edema in Samoa. Methods: The number of cases in this study was 128, They were all from patients with diabetic retinopathy complicated with macular edema admitted to the TTM Hospital in Samoa between January 2024 and June 2024, All patients were divided into control and observation groups according to the different treatment methods, In which the control group applied retinal laser photocoagulation, The observation group was combined with intravitreal injection of anti-VE GF drugs based on the control group, And a comparative analysis of the treatment effect, retinal thickness, best corrected visual acuity, intraocular pressure, SDF-1, VE GF, PDGF, CLVQOL, and complication rate in both groups. Results: After intervention, the overall response rate was higher and statistically significant (P <0.05); better retinal thickness, best corrected visual acuity, and IOP were statistically significant (P <0.05); higher CLVQOL score and statistically significant (P <0.05); and no significant difference in complication rate between the two groups (P> 0.05). Conclusion: The treatment of patients with diabetic retinopathy with macular edema combined with VE GF drugs and retinal laser photocoagulation has obvious advantages, which can effectively improve the retinal thickness, best corrected visual acuity, intraocular pressure and CLVQOL score, and is worth promoting in clinical practice.

Vitreo; Anti-VE GF drug; Retinal laser photocoagulation; Diabetic retinopathy; Macular edema