妊娠期阻塞性睡眠呼吸暂停低通气综合征对母儿结局影响-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

妊娠期阻塞性睡眠呼吸暂停低通气综合征对母儿结局影响

Effect of obstructive sleep apnea hypopnea syndrome in pregnancy on maternal and infant outcomes

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DOI	10.12208/j.ijcr.20240172
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2024, 8(5)
作者	张丽敏,刘丽*,
作者单位	广西壮族自治区柳州市工人医院广西柳州 ;
摘要	探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）对晚期妊娠肥胖孕妇的影响。方法本研究为回顾性分析，对象为2020年03月至2021年03月在柳州市工人医院产检行OSAHS筛查的晚期妊娠肥胖孕妇58例。根据是否患有OSAHS，将参与者分为OSAHS组（25例）和无OSAHS组（33例）。通过便携式睡眠监测仪对所有孕妇进行筛查，诊断OSAHS，并记录临床特征及母儿妊娠结局。结果 OSAHS组中妊娠晚期肥胖孕妇的孕前体重指数显著高于无OSAHS组（P<0.05）。OSAHS孕妇在妊娠期高血压疾病、分娩时BMI、分娩孕周及新生儿出生体重方面，与无OSAHS组相比均有显著差异（P<0.05）。其他妊娠相关并发症如妊娠期糖尿病、早产等差异无统计学意义（P>0.05）。结论 OSAHS在晚期妊娠肥胖孕妇中较为常见，与多种不良妊娠结局相关。识别并管理孕期OSAHS可能对降低妊娠并发症风险、改善母儿健康结局具有重要意义。
Abstract	Objective To investigate the effects of obstructive sleep apnea hypopnea syndrome (OSAHS) on obese pregnant women in the third trimester. Methods This study was a retrospective analysis, and the subjects were 58 obese pregnant women in the third trimester who underwent OSAHS screening in the obstetrical examination of Liuzhou Workers Hospital from March 2020 to March 2021. Participants were divided into OSAHS group (25 cases) and OSAHS-free group (33 cases) according to whether they had OSAHS or not. All pregnant women were screened with portable sleep monitors to diagnose OSAHS, and clinical features and maternal and maternal pregnancy outcomes were recorded. Results The pre-pregnancy body mass index of obese pregnant women in the third trimester of pregnancy in OSAHS group was significantly higher than that in OSAHS group (P<0.05). There were significant differences in hypertensive diseases during pregnancy, BMI at delivery, gestational weeks and birth weight of newborns in OSAHS pregnant women compared with those without OSAHS (P<0.05). There was no significant difference in other pregnancy-related complications such as gestational diabetes mellitus and preterm birth (P>0.05). Conclusion OSAHS is common in obese pregnant women in the third trimester and is associated with a variety of adverse pregnancy outcomes. Identification and management of OSAHS during pregnancy may be of great significance in reducing the risk of pregnancy complications and improving maternal and infant health outcomes.
关键词	阻塞性睡眠呼吸暂停低通气综合征（OSAHS）；妊娠；肥胖；妊娠并发症；妊娠结局
KeyWord	Obstructive sleep apnea hypopnea syndrome (OSAHS); Pregnancy; Obesity; Pregnancy complications; Pregnancy outcome
基金项目
页码	45-48

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引用本文

张丽敏,刘丽*. 妊娠期阻塞性睡眠呼吸暂停低通气综合征对母儿结局影响 [J]. 国际临床研究杂志. 2024; 8; (5). 45 - 48.

文献评论

王**上海市第****** 已认证✔

2025-11-07 08:15:16

本研究通过回顾性分析，探讨了OSAHS对晚期妊娠肥胖孕妇母儿结局的影响，发现OSAHS组在妊娠期高血压疾病、分娩孕周、新生儿出生体重等方面有显著差异。研究选题具有临床意义，设计清晰，数据分析方法基本恰当。然而，研究在样本量、混杂因素控制、机制探讨深度等方面存在一定局限性。 1. 研究设计与方法样本量偏小：共58例患者，OSAHS组仅25例，统计效能有限，尤其在对罕见结局（如死胎/死产）的分析中可能产生偏倚。回顾性设计的局限性：存在信息偏倚和混杂偏倚的风险，尽管两组在年龄、初产妇比例等方面无差异，但孕前BMI存在显著差异，这可能是一个重要的混杂因素。 OSAHS诊断方法：使用便携式睡眠监测仪是可行的，但建议说明其与多导睡眠图（PSG）的一致性，以增强诊断的可信度。 2. 数据与结果分析表2数据不一致：无OSAHS组例数在表头为33例，表中为32例，需核对数据一致性。 “产后出血”与“伤口并发症”P值异常：两项P值均报告为0.000，建议核实统计方法是否正确（如Fisher精确检验），并报告具体P值。 GDM无统计学差异但趋势明显：OSAHS组GDM发生率为13/25（52%），非OSAHS组为9/33（27.3%），P=0.055，虽未达统计学意义，但临床差异显著，建议在讨论中进一步说明其潜在意义。

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