Journal of International Psychiatry

Objective: To analyze the therapeutic effect of diazepam in severe preeclampsia and its effect on psychological stress, maternal and infant outcomes and oxidative stress response. Methods: a total of 95 patients with severe preeclampsia admitted to our department from September 2020 to November 2021 were selected as the research objects and grouped by coin toss method. 47 cases in control group were treated with magnesium sulfate and nifedipine tablets, and 48 cases in observation group were treated with diazepam. Psychological stress level, oxidative stress response, maternal and infant outcomes and adverse reactions were compared between the two groups. Results: The scores of self-rating Depression Scale (SDS) and self-rating anxiety Scale (SAS) in the observation group were lower than those in the control group (P < 0.05). The level of late oxidized protein product (AOPP) in observation group was lower than that in control group, and the level of glutathione peroxidase (GSH-Px) was higher than that in control group (P < 0.05). The incidence of premature delivery, cesarean section, postpartum hemorrhage and neonatal asphyxia in the observation group were lower than those in the control group (P < 0.05). The incidence of adverse reactions was compared between the two groups (P > 0.05), and the incidence of adverse reactions was low.Conclusion: Diazepam combined with conventional treatment for severe preeclampsia has definite effect, can reduce oxidative stress response, improve maternal and infant outcomes, regulate psychological stress state, and has high safety, worthy of clinical application.

Key words: diazepam; Severe preeclampsia; Psychological stress; Maternal and infant outcomes; Oxidative stress response