| Abstract |
[Abstract] Objective To investigate the effect of remazolam on the recovery effect and cognitive function of elderly patients after hip replacement. Methods A total of 100 elderly patients with hip replacement in our hospital from October 2019 to October 2021 were the subjects of this study, and randomly divided into two groups by digital table method. The control group was treated with midazolam, sufentanil, and rocuronium bromide for induction of anesthesia, while the observation group was treated with remazolam, sufentanil, and rocuronium bromide for anesthesia induction. The intraoperative conditions, postoperative recovery time such as eye opening and extubation time, and postoperative respiratory depression, agitation and other complications were compared between the two groups. The Mini-Mental State Evaluation Scale (MMSE) scores were evaluated before surgery and at 12h, 1d, and 3d after surgery. Results There was no significant difference in operation time and blood loss between the two groups (P>0.05). The postoperative eye-opening time and extubation time of the observation group were significantly lower than those of the control group (P<0.05). The incidence of postoperative complications such as cognitive dysfunction and restlessness in the observation group was significantly lower than that in the control group (P<0.05). There was no significant difference in the incidence rates of respiratory depression, dizziness, headache, nausea and vomiting (P>0.05). The MMSE scores at 12h and 1d after operation in the two groups were lower than those before operation, but the observation group was significantly higher than the control group (P<0.05). There was no significant difference in MMSE scores between the two groups at 3 days after operation (P>0.05). Conclusion Compared with the conventional drug midazolam, remazolam can improve the quality of postoperative recovery, reduce the incidence of complications such as restlessness and cognitive dysfunction, and reduce early postoperative cognitive dysfunction.
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