Journal of International Psychiatry

【 Abstract 】 Objective To explore the correlation between the change of thyroid stimulating hormone level in early and late pregnancy and postpartum depression, and to provide evidence for clinical diagnosis and treatment. Methods 210 pregnant women admitted to our hospital from January 2020 to December 2021 were selected. Serum free triiodide thyroid adenionine (FT3), serum free thyroxine (FT4) and thyroid stimulating hormone (TSH) were detected in the early and late stages of pregnancy, respectively. The presence of postpartum depression was assessed by using the Edinburgh Gestational Depression Scale (EPDS) within 1 week after delivery. The patients were divided into postpartum depression (PPD group) and non-PPD group, and the correlation between thyroid hormone level and PPD disease was analyzed. Results: FT4 and FT3 in PPD group were lower than those in non-PPD group, and TSH was higher than those in non-PPD group, with statistical significance (P<0.05). There was no statistical significance in FT3, FT4 and TSH levels in the two groups during late pregnancy (P>0.05). According to binary logistic regression analysis, FT3, FT4 and TSH levels in early pregnancy were negatively correlated with the occurrence of PPD. Conclusion: FT3, FT4 and TSH levels in early pregnancy can predict the occurrence of PPD disease.

【 Key words 】 postpartum depression; Thyroid stimulating hormone; Early pregnancy; Late pregnancy