| Abstract |
[Abstract] Objective To discuss the relationship between cognitive impairment (CI) and serum homocysteine (Hcy), amyloid A (SAA) and Tau protein in ischemic stroke (IS). Methods A total of 110 IS patients in our hospital from February 2020 to February 2022 were selected as the research subjects. The occurrence of CI and medical records such as gender, age, and comorbidities were investigated. Serum Hcy, SAA and Tau protein levels were detected. The medical records and serum indexes of patients in CI group and non-CI group were compared. Multivariate analysis was used to analyze its relationship with post-IS CI. Results 52 cases of CI were detected in 110 IS patients, and the detection rate was 47.27%. There were statistically significant differences in age, education level, National Institutes of Health Stroke Scale (NHISS) score, and infarct site involving frontal or temporal lobe between CI group and non-CI group (P<0.05). There was no significant difference in gender, marriage and residence between the two groups (P>0.05). The levels of serum Hcy, SAA and Tau protein in the CI group were higher than those in the non-CI group. Multivariate analysis showed that the education level of primary school and below, the infarct site involving the frontal or temporal lobe, NHISS score, serum Hcy, SAA, and Tau protein levels were the risk factors for CI after IS. Conclusion The incidence of CI is higher after IS, and the risk factors include educational level, infarct site, and neurological function, and high levels of serum Hcy, SAA, and Tau protein can also increase the risk of CI.
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