Journal of International Psychiatry

[Abstract] Objective: To explore the clinical treatment effect of naloxone in patients with antispermatogenic drug poisoning and its influence value on patients prognostic cognitive function and negative emotions. Method: choose 2020 from April to October 2021 during 109 antipsychotic poisoning patients as the research object, according to random number table method, it can be divided into two groups, the control group in 54 patients with symptomatic treatment, observation group 55 cases on the basis of conventional treatment increase naloxone treatment, compared two groups of patients the indicators. Results: After treatment, the Glasgow Coma scale (GCS) in the observation group was higher than that in the control group, and the wake-up time and maintenance time of symptoms after awakening in the observation group were lower than those in the control group (P < 0.05). After 1 week and 2 weeks of successful treatment, the scores of self-rating anxiety scale (SAS) and Self-rating Depression Scale (SDS) in the observation group were lower than those in the control group, and the mini-Mental State Examination (MMSE) score was higher than that in the control group (P < 0.05). After 2 weeks of successful treatment, there was no significant difference in the RSESE score between the two groups (P > 0.05), but the Social Dysfunction Screening Scale (SDSS) score of the observation group was lower than that of the control group (P < 0.05). There was no significant difference in the incidence of complications between the two groups (P > 0.05). Conclusion: Naloxone can improve the clinical diagnosis and treatment effect of patients, reduce the level of negative emotions, improve the level of cognitive function, social function, and high safety.

【Key words】: Naloxone; Poisoning with antipsychotics; Negative emotions; Extracorporeal adverse reactions; Cognitive function