| Abstract |
Objective To explore the correlation between the expression levels of serum CD30, BAFF, sTNF-R1, CXCL10 and different emotional states in patients with bipolar disorder. Methods A total of 80 patients with bipolar disorder diagnosed in Hunan Provincial Brain Hospital from September 2020 to March 2023 were selected and divided into a manic episode group of 50 patients and a depressive episode group of 30 patients based on diagnostic criteria. Forty healthy individuals from Hunan Provincial Brain Hospital were selected as a control group. The expression levels of serum CD30, BAFF, sTNF-R1, and CXCL10 were measured by enzyme linked immunosorbent assay. The clinical symptoms of patients were evaluated using the Hamilton Depression Scale and the Youngs Mania Rating Scale. Results Compared with the healthy control group, the expression levels of CD30 and BAFF in the manic episode group were higher (P<0.001), while the expression levels of CXCL10 were lower (P<0.001), and the difference in the expression levels of sTNF-R1 was not significant (P>0.05). Compared with the healthy control group, the expression levels of CD30 and BAFF in the depressive episode group were higher (P<0.001), while the expression levels of sTNF-R1 and CXCL10 were not significantly different (P>0.05). Compared with the depressive episode group, the manic episode group had higher levels of BAFF and sTNF-R1 expression (P<0.01), lower levels of CXCL10 expression (P<0.001), and no significant difference in CD30 expression (P>0.05). CXCL10 in patients with depressive episodes was significantly positively correlated with total HAMD scores, anxiety/somatization factor scores, and cognitive impairment factor scores. Conclusions CD30 and BAFF may be biomarkers for the diagnosis of bipolar disorder, and CXCL10 may be biomarkers for the diagnosis of manic episodes. BAFF, sTNF-R1, and CXCL10 may become state markers for diagnosing different emotional states in patients with bipolar disorder. The level of CXCL10 of patients with bipolar disorder may be related to the depression, anxiety, and cognitive impairment in patients with depressive episodes.
|