Journal of International Psychiatry

Objective: To explore synergia of Aripiprazole, and the curative effect, tolerance and improvement of social function of Votioxetine in the treatment-resistant depression(TRD).Methods:70 outpatients or inpatients with TRD in our hospital from January 2020 to December 2020 were selected as the object of study. The patients were randomly divided into control group (n =35) and treatment group (n =35). The control group was treated with systemic therapy of Votioxetine after one week of washing period. The initial dose of 10mg/d was taken orally, and the dose was added gradually to 20mg/d one week later. In the treatment group, Aripiprazole was taken orally on the basis of the control group, and the initial dose of Aripiprazole was taken orally by 5mg/d, which was gradually increased to 5-10mg/d within one week. Patients in both groups were treated continuously for 8 weeks. The clinical effects of the two groups were observed, and Hamilton Depression scale (HAMD) score, SDS score and TESS score were performed at different time points.Results: After 8 weeks of treatment, the effective rate was 88.6% in the treatment group and 68.6% in the control group. There was significant difference between the two groups (P < 0.05). The HAMD of both groups decreased significantly at the end of the 2nd, 4th and 8th week, and the score of the treatment group decreased more significantly at the end of the2th、 4th、8th week (P < 0.05). The recovery of social function was more significant in the treatment group at the end of 8 weeks, compared with the initial stage of treatment, the difference was statistically significant (P < 0.05).Conclusion: Votioxetine combined with Aripiprazole is more effective in the treatment of TRD, and the recovery of social function is relatively fast and safe.

Key words: treatment-resistant depression(TRD); Votioxetine, Aripiprazole.