Journal of International Psychiatry

[Abstract] Objective To observe the clinical efficacy of agomelatine combined with traditional Chinese medicine fumigation in the treatment of senile depression (LLD) with insomnia. Methods 76 elderly patients with depression and insomnia treated in Shenyang mental health center from May 2019 to December 2020 were randomly divided into routine treatment group (38 cases) and observation group (38 cases). The routine treatment group was treated with agomelatine orally, and the observation group was treated with traditional Chinese medicine fumigation for 8 weeks. The changes of Hamilton Depression Scale (HAMD) score and Pittsburgh sleep quality index (PSQI) score after treatment were observed, and the change trend of serum homocysteine (Hcy) was observed. Results before treatment, there was no significant difference in HAMD, PSQI and Hcy between the two groups (P < 0.05); After 8 weeks of treatment, the total effective rate of the observation group was higher than that of the routine treatment group, and the sleep improvement rate was higher than that of the routine treatment group (P < 0.05). The Hcy concentration of the two groups after treatment was lower than that before treatment, the difference was statistically significant (P < 0.05), and the Hcy concentration of the observation group after treatment was lower than that of the routine treatment group, the difference was statistically significant (P < 0.05). Conclusion traditional Chinese medicine fumigation therapy can effectively improve the clinical efficacy and sleep of elderly patients with depression and insomnia, and has the advantages of safety, less side effects and comfortable experience, which is worthy of clinical promotion.

[Key words] Senile depression; Agomelatine; Traditional Chinese medicine fumigation therapy; Homocysteine