艾司西酞普兰联合抗生素治疗慢性盆腔炎患者的效果及对抑郁/焦虑不良情绪及神经递质的影响
Efficacy of escitalopram combined with antibiotics in the treatment of patients with chronic pelvic inflammatory disease and its effects on depression/anxiety, negative emotions and neurotransmitters
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2023, 50(3) |
| 作者 |
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| 作者单位 |
濮阳市安阳地区医院妇产科 ;
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| 摘要 |
【摘要】目的：探究慢性盆腔炎患者应用艾司西普兰联合抗生素的效果及对神经递质、抑郁/焦虑不良情绪的影响。方法：选取我科2020年7月至2021年7月期间83例慢性盆腔炎患者作为研究对象，对照组41例给予抗生素治疗，观察组42例增加艾司西酞普兰治疗，对比两组患者临床疗效、神经递质水平、炎性因子水平及不良情绪。结果：治疗后，观察组患者5-羟色胺（5-HT）、去甲肾上腺素（NE）水平均高于对照组（P<0.05）；观察组汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分均低于对照组（P<0.05）；观察组C反应蛋白(CRP)、降钙素原（PCT）水平低于对照组（P<0.05），白细胞介素-2（IL-2）水平高于对照组（P<0.05）；观察组治疗总有效率95.23%高于对照组75.60%（P<0.05）。结论：抗生素联合艾司西酞普兰治疗慢性盆腔炎抑郁/焦虑患者效果显著，能有效降低患者炎症因子水平，提高神经递质水平，改善抑郁、焦虑不良情绪，提升临床治疗效果，安全性高。
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| Abstract |
【Abstract】Objective: To explore the effect of escipram combined with antibiotics in patients with chronic pelvic inflammatory disease and its effects on neurotransmitters, depression/anxiety and negative emotions. Methods: Selected 83 patients with chronic pelvic inflammatory disease in our department from July 2020 to July 2021 as the research objects, 41 patients in the control group were treated with antibiotics, and 42 patients in the observation group were treated with escitalopram. Efficacy, neurotransmitter levels, inflammatory factor levels and adverse mood. Results: After treatment, the levels of serotonin (5-HT) and norepinephrine (NE) in the observation group were higher than those in the control group (P<0.05). (HAMA) scores were lower than those in the control group (P<0.05); the levels of C-reactive protein (CRP) and procalcitonin (PCT) in the observation group were lower than those in the control group (P<0.05), interleukin-2 (IL- 2) The level was higher than that of the control group (P<0.05); the total effective rate of the observation group was 95.23% higher than that of the control group (75.60%) (P<0.05). Conclusion: Antibiotics combined with escitalopram in the treatment of chronic pelvic inflammatory disease depression/anxiety patients has a significant effect, can effectively reduce the level of inflammatory factors, improve the level of neurotransmitters, improve depression, anxiety and negative emotions, improve clinical treatment effect, and has high safety.
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| 关键词 |
【关键词】艾司西酞普兰；慢性盆腔炎；神经递质
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| KeyWord |
【Key words】escitalopram; chronic pelvic inflammatory disease; neurotransmitter
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| 基金项目 |
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| 页码 |
518-520 |
徐流立*.
艾司西酞普兰联合抗生素治疗慢性盆腔炎患者的效果及对抑郁/焦虑不良情绪及神经递质的影响 [J].
国际精神病学杂志.
2023; 50; (3).
518 - 520.