Journal of International Psychiatry

[Abstract] Objective: To explore the relationship between serum homocysteine (Hcy) level and cognitive impairment in first-episode schizophrenia. Methods: 92 first-episode schizophrenic patients admitted from February 2020 to May 2022 were included in the observation group, and 90 health examination personnel at the same stage were included in the control group; Detect the serum Hcy value and determine the detection of homocysteine (HHcy). The determination standard is that the Hcy is greater than 15 umol/L; The patients in the observation group were assessed with the Positive and Negative Symptom Scale (PANSS), the Cognitive Function Test Consensus Version of Schizophrenia (MCCB), and the Wisconsin Card Sorting Test (WCST); The relationship between serum Hcy and cognitive impairment was analyzed. Results: The level and detection rate of Hcy in the observation group were significantly higher than those in the control group (P; Compared with the non-HHcy group, the number of correct answers and completed classification of WCST in HHcy group was significantly lower, and the number of wrong answers, continuous answers and non-sustainable answers were significantly higher (P<0.05); Compared with non-HHcy group, the MCCB score of HHcy group was significantly lower (P; Correlation analysis: The level of serum Hcy was negatively correlated with the number of correct answers, the number of completed classification and MCCB of WCST (P<0.05); It was positively correlated with the number of incorrect answers, continuous answers and non-sustained answers of WCST (P<0.05). Conclusion: The level of Hcy in first-episode schizophrenics is significantly higher than that in healthy people, which is positively correlated with the impairment of cognitive function of patients, and can be used as an auxiliary indicator for laboratory diagnosis.

[Key words] First-episode schizophrenia; Homocysteine; Cognitive impairment; relevance