Journal of International Psychiatry

Abstract Objective:To explore the effect of high frequency repetitive transcranial magnetic stimulation (rTMS) combined with ziprasidone in the treatment of schizophrenia .Methods:Ninety-two schizophrenic patients admitted to the Department of Psychiatry of Fuyang Third Peoples Hospital were randomly divided into two groups. 46 patients in the control group were treated with ziprasidone, and 46 patients in the combination group were treated with high-frequency rTMS and ziprasidone. After 2 weeks of continuous treatment, blood samples were collected to measure the neurofunction-related factors, and to assess cognitive function The scores of positive and negative symptoms scale (PANSS) were compared with the clinical efficacy and adverse reactions of the two groups.Results:① The total clinical effective rate of the combined group (89.13%) was significantly higher than that of the control group (76.09%)；② Compared with the control group after treatment, the serum GFAP in the combined group decreased more significantly, and the serum NGF, BDNF levels and LOTCA scores increased more significantly after treatment ; ③ Compared with before treatment, the levels of serum TC and FPG in the two groups increased after treatment, and the difference was statistically significant; Compared with the control group after treatment, the levels of serum TC and FPG after combined treatment were lower, and the difference was statistically significant ; ④ There was no statistical difference in the incidence of adverse reactions between the two groups (15.21% vs 13.04%).Conclusion:High-frequency rTMS combined with ziprasidone is effective in the treatment of schizophrenic patients, which can improve the level of BDNF and cognitive function of patients, and has clinical promotion value.

Key words：Ziprasidone; High-frequency rTMS; Schizophrenia; Brain derived neurotrophic factor; cognitive function