丁螺环酮治疗精神分裂症阴性症状的效果及对认知功能的影响
Effect of buspirone combined with escitalopram on negative symptoms of schizophrenia and its influence on cognitive function
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2023, 50(4) |
| 作者 |
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| 作者单位 |
阜阳市第三人民医院精神科 ;
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| 摘要 |
【摘要】探讨丁螺环酮治疗精神分裂症（SP）阴性症状的效果及对认知功能的影响。方法 选取2019年1月~2022年10月医院收治的82例SP阴性症状患者，依照随机数表法分为对照组和观察组，各41例。对照组采用氨磺必利治疗，观察组采用氨磺必利+丁螺环酮治疗，两组均治疗12周。对比PANSS、SANS评分、临床疗效，精神分裂症认知功能成套测验共识版（MCCB）、个人与社会量表（PSP）评分、神经功能因子［S100β蛋白（S100β）、髓鞘碱性蛋白（MBP）］及不良反应。结果 观察组治疗后PANSS评分、SANS评分均低于对照组（P均＜0.05）。观察组治疗后疗效优于对照组（P＜0.05）。观察组治疗后MCCB评分、PSP评分高于对照组（P均＜0.05）。观察组治疗后S100β、MBP水平低于对照组（P均＜0.05）。观察组未出现明显不良反应。结论 SP阴性症状患者用氨磺必利联合丁螺环酮治疗可缓解临床症状、提高临床疗效、改善认知功能和社会功能，调节神经功能因子水平。
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| Abstract |
【Abstract】Objective To investigate the effect of buspirone on negative symptoms of schizophrenia (SP) and its influence on cognitive function. Methods From January 2019 to October 2022, 82 patients with negative SP symptoms were selected and divided into control group and observation group according to random number table method, with 41 cases in each group. The control group was treated with amsulapride, and the observation group was treated with amsulapride + buspirone Both groups were treated for 12 weeks. PANSS, SANS score, clinical efficacy, cognitive function Kit Consensus version (MCCB), Personal and Social Scale (PSP) score, neurological function factors [S100β protein (S100β), myelin basic protein (MBP)] and adverse reactions were compared. Results PANSS score and SANS score in the observation group were lower than those in the control group after treatment (P< 0.05). The curative effect of the observation group was better than that of the control group (P<0.05). The MCCB score and PSP score of the observation group were higher than those of the control group after treatment (P< 0.05). The levels of S100β and MBP in observation group were lower than those in control group after treatment (P<0.05). There was no obvious adverse reaction in the observation group. Conclusion SP-negative patients treated with amsulapride + buspirone can relieve clinical symptoms, improve clinical efficacy, improve cognitive function and social function, and regulate the level of neurofunctional factors.
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| 关键词 |
【关键词】 精神分裂症；阴性症状；丁螺环酮；认知功能
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| KeyWord |
【Key words】Schizophrenia; Negative symptoms; Buspirone; Escitalopram; cognitive function
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| 基金项目 |
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| 页码 |
659-662 |
王雪亚*.
丁螺环酮治疗精神分裂症阴性症状的效果及对认知功能的影响 [J].
国际精神病学杂志.
2023; 50; (4).
659 - 662.