抑郁症患者睡眠结构与自杀风险的相关性研究

Relationship between sleep structure and suicide risk in patients with depression

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2023, 50(4)
作者
作者单位

广州医科大学附属脑科医院 ;

摘要
探究抑郁症患者多导睡眠图(polysomnography,PSG)参数特征对自杀风险的影响。方法 回顾性收集176例抑郁症住院患者的人口学资料、临床特征及PSG参数,依据入院时采用自杀风险评估表(The Nurses Global Assessment of Suicide Risk,NGASR)评估患者自杀风险,按评分标准分为非高自杀风险组和高自杀风险组,比较PSG参数组间差异。结果 非高自杀风险组和高自杀风险组在年龄(t=2.904,p=.004)、受教育年限(Z=-2.621,p=.009)、婚姻(χ2=10.348,p=.000)、抑郁自评量表(Z=-2.796,p=.005)、焦虑自评量表(Z=-2.115,p=.034)、REM潜伏期(Z=-2.591,p=.010)方面差异有统计学差异。logistic回归提示抑郁症患者REM潜伏期缩短与自杀风险相关(OR=0.284,95%CI:0.128,0.629,p<0.05),在校正人口学资料及临床特征后,相关性仍然显著(OR=0.362,95%CI:0.136,0.964,p<0.05)。结论 抑郁症患者睡眠指标是自杀风险的相关影响因素,REM潜伏期可能作为抑郁症自杀风险的检测指标。
Abstract
Objective To explore the effects of polysomnography (PSG) parameters and suicide risk in patients with depression. Methods The demographic data, clinical characteristics and PSG parameters of 176 inpatients with depression were retrospectively collected, and the suicide risk of the patients was assessed using The Nurses Global Assessment of Suicide Risk (NGASR) at the time of admission. Divided into non-high suicide risk group and high suicide risk group, and compared the differences between groups in PSG parameters. Results There were significant differences between the two groups in age(t=2.904, p=. 004), years of education (Z= -2.621, p=. 009), marriage (χ2=10.348, p=. 000), Self-rating Depression Scale (Z= -2.796, p=. 005), Self-rating Anxiety scale (Z= -2.115, p=. 034), REM latency (Z= -2.591, p=. 010). Logistic regression analysis showed that shortened REM latency was associated with suicide risk(OR=0.284,95%CI:0.128,0.629,p<0.05), and after adjusting for demographic data and clinical characteristics, the correlation was still significant (OR=0.362, 95%CI: 0.136, 0.964, P<0.05). Conclusion Sleep index is related to suicide risk in patients with depression, and REM latency may be used as a detection index of suicide risk in depression.
关键词
抑郁症;自杀风险;多导睡眠图
KeyWord
Depression; Suicide risk; Polysomnography
基金项目
页码 719-722
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范雪菲,马亚荣,邱允,贺丽花,江帆,何红波*. 抑郁症患者睡眠结构与自杀风险的相关性研究 [J]. 国际精神病学杂志. 2023; 50; (4). 719 - 722.

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