文拉法辛和艾司西酞普兰治疗抑郁症的效果比较及有效率分析
Comparison and analysis of the efficacy of venlafaxine and escitalopram in the treatment of depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2023, 50(4) |
| 作者 |
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| 作者单位 |
首都医科大学宣武医院 药剂科 ;
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| 摘要 |
【摘要】目的：探讨文拉法辛和艾司西酞普兰在抑郁症治疗中的实际应用效果。方法：遵循随机原则，选择2020年1月~2022年5月在我院确诊为抑郁症的100例患者，以入院单双数为基准实施分组，单数为对照组实施文拉法辛治疗，双数为观察组实施艾司西酞普兰治疗，每组50例。分析药物的临床疗效；评价治疗前后抑郁评分、睡眠状态及自主神经功能，同时就用药后不良反应发生率进行记录。结果：观察组的临床疗效96.00%，高于对照组的84.00%，差异存在统计意义（P<0.05）；经治疗后，观察组抑郁评分、睡眠质量评分，相较于对照组降低（P<0.05），自主神经功能评分相对于对照组升高；观察组不良反应发生率为(16.00%)，相较于对照组（18.00%）无明显变化（P>0.05）。结论：在对抑郁症治疗中选择艾司西酞普兰可通过合理给药控制患者病情，并改善其抑郁状态及睡眠质量，达到促进神经功能恢复的目的，减轻抑郁症对机体的损害。
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| Abstract |
[Abstract] Objective: To explore the practical effect of venlafaxine and escitalopram in the treatment of depression. Methods: Following the principle of randomization, 100 patients with depression diagnosed in our hospital from January 2020 to May 22 were selected and divided into groups based on the admission of single and double numbers. The singular number was treated with venlafaxine in the control group, and the double number was treated with escitalopram in the observation group, with 50 patients in each group. Analyze the clinical efficacy of the drug; The depression score, sleep status and autonomic nervous function were evaluated before and after treatment, and the incidence of adverse reactions after treatment was recorded. Results: The clinical efficacy of the observation group was 96.00%, higher than that of the control group (84.00%), with statistical significance (P<0.05); After treatment, the depression score and sleep quality score of the observation group were lower than those of the control group (P<0.05), and the autonomic nervous function score was higher than that of the control group; The incidence of adverse reactions in the observation group was (16.00%), and there was no significant change compared with the control group (18.00%) (P>0.05). Conclusion: In the treatment of depression, escitalopram can control the patients condition, improve their depressive state and sleep quality, promote the recovery of nervous function, and reduce the damage of depression to the body.
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| 关键词 |
关键词：文拉法辛；艾司西酞普兰；抑郁症；睡眠质量；自主神经功能
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| KeyWord |
Key words: venlafaxine; Acecitalopram; depression; Sleep quality; Autonomic nerve function
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| 基金项目 |
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| 页码 |
726-728 |
裴剑楠*.
文拉法辛和艾司西酞普兰治疗抑郁症的效果比较及有效率分析 [J].
国际精神病学杂志.
2023; 50; (4).
726 - 728.