Journal of International Psychiatry

Objective： To explore the therapeutic effect and predictive factors of low frequency repetitive transcranial magnetic stimulation (rTMS) on different target areas for obsessive compulsive disorder (OCD). Methods： 93 OCD patients were randomly divided into three groups, drug group was treated with sertraline, SMA group was treated with sertraline and 1Hz rTMS on the supplementary motor area (SMA) , and DLPFC group was treated with sertraline and 1Hz rTMS on the dorsolateral region of the right frontal lobe (right DLPFC), respectively, 20 times for 4 weeks. The treatment efficacy and function were evaluated by Yale-Brown Obsessive Compulsive Scale (Y-BOCS) , Hamilton Anxiety Scale（HAMA）, Hamilton Depression Scale (HAMD) and Global Assessment of Function (GAF) before and after treatment. In addition, the predictive factors were analyzed by the related clinical factors. Results： After treatment, compared with drug group, the scores of effective rate, obsessive behavior and HAMA of SMA group and DLPFC group were significantly different (P <0.05). A higher Y-BOCS score before treatment may be negatively correlated with the effective response to rTMS treatment. Conclusions： Low frequency rTMS on both SMA and right DLPFC are effective for OCD, but there is no significant difference between the two target areas. Higher Y-BOCS score before treatment may be a predictor of poor efficacy of rTMS for OCD.

Obsessive compulsive disorder; Repetitive transcranial magnetic stimulation; Supplementary motor area; Dorsolateral region of the right frontal lobe; Predictive factor