| Abstract |
[Abstract] Objective: To observe the efficacy of oxcarbazepine (OXC) + levetiracetam (Lev) in the treatment of cognitive impairment in adult patients with temporal lobe epilepsy. Methods: 70 adult patients with temporal lobe epilepsy from January 2020 to October 2022 were randomly divided into observation group (35 cases were included and treated with OXC + Lev) and control group (35 cases were included and treated with OXC). The P300 latency and amplitude, clinical memory scale (CMS), adult Wechsler Intelligence Scale (WAIS-RC) and adverse reactions were evaluated. Results: (1) there was no significant difference in P300 latency and amplitude (P3 amplitude, N2 latency and P2 latency) between the groups before treatment, P > 0.05; After 3 months of treatment, there was no significant difference in P3 amplitude between the groups (P > 0.05), but the latency of N2 wave and P2 wave in the observation group were shorter (P < 0.05); (2) Before treatment, there was no significant difference in CMS score (image free memory, associative memory and pointing memory) between the groups (P > 0.05); After 3 months of treatment, there was no significant difference in associative memory scores between the groups (P > 0.05), but the scores of image free recall and pointing memory in the observation group were higher (P < 0.05); (3) Before treatment, there was no significant difference in WAIS-RC scores [PIQ, VIQ and FIQ] between the groups (P > 0.05); After 3 months of treatment, there was no significant difference in PIQ and VIQ scores between the groups (P > 0.05), but the FIQ score in the observation group was higher (P < 0.05); (4) In terms of adverse reactions, there was no significant difference between the observation group (8.57%) and the control group (5.71%), P > 0.05, and there were no serious adverse reactions, electrolyte, liver and kidney function and other obvious abnormalities. Conclusion: OXC + Lev treatment for adult patients with temporal lobe epilepsy can enhance the curative effect and improve cognitive impairment, which is worth popularizing.
|