Journal of International Psychiatry

Abstract: Objective To investigate the effect of the second generation antipsychotic drug amisulpride on Neutrophil to lymphocyte ratio (NLR) and the risk factors of abnormal electrocardiogram in patients with schizophrenia. Methods Collect 88 patients with schizophrenia who were treated with oral Amisulpride. Among them, 40 cases with electrocardiogram abnormality during the treatment were classified as the study group, and 48 cases without electrocardiogram abnormality were classified as the control group. The demographic and general clinical data and NLR of the two groups were compared, and the influencing factors of electrocardiogram abnormalities caused by oral Amisulpride treatment were analyzed. Results The differences between the study group and the control group in terms of medication dose, titration time, blood potassium level, and NLR are statistically significant (all P<0.05). The NLR of patients with electrocardiogram abnormalities is significantly positively correlated with the dose of Amisulpride used (P=0.029). Multiple logistic regression analysis showed that NLR level, titration time, drug dose, and blood potassium level are important risk factors for Amisulpride-induced electrocardiogram abnormalities (all P<0.05). Conclusions High doses of Amisulpride, short titration time, high NLR levels, and low blood potassium levels are important risk factors for the occurrence of electrocardiogram abnormalities.

Key words: amisulpride; Second generation antipsychotic drugs；Electrocardiogram abnormality; schizophrenia