重复经颅磁刺激联合文拉法辛对更年期伴抑郁女性睡眠质量和性激素水平的影响
Effects of repetitive transcranial magnetic stimulation combined with venlafaxine on sleep quality and sexual hormone levels in menopausal women with depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2023, 50(5) |
| 作者 |
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| 作者单位 |
简阳市妇幼保健院 产后保健科 ;
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| 摘要 |
摘要 目的：探讨对更年期伴抑郁女性采用重复经颅磁刺激（rTMS）结合文法拉辛的应用效果。方法：选取本院2020年6月-2021年12月期间收治的更年期伴抑郁女性患者110例，根据数字随机法将其分为对照组和观察组，各55例。其中对照组给予常规治疗结合文拉法辛治疗，观察组在对照组基础上联合rTMS进行治疗。比较两组治疗前后抑郁程度、睡眠质量、性激素水平[雌二醇（E2）、促卵泡生成激素（FSH）、5-羟色胺（5-HT）]。结果：治疗后，观察组FSH水平以及HAMD、CES-D、睡眠质量各项评分及总分均明显低于对照组，5-HT、E2水平均显著高于对照组（P<0.05）。结论：临床针对更年期伴抑郁的女性患者采用rTMS联合文拉法辛治疗效果确切，值得临床应用。
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| Abstract |
Abstract Objective:Explore the application effect of repetitive transcranial magnetic stimulation (rTMS) combined with grammar rasine in menopausal women with depression.Methods:110 female patients with menopausal depression admitted to our hospital from June 2020 to December 2021 were selected and randomly divided into a control group and an observation group, with 55 patients in each group. The control group was treated with routine treatment combined with venlafaxine, and the observation group was treated with rTMS on the basis of the control group. Compare the levels of depression, sleep quality, and sexual hormones (estradiol (E2), follicle stimulating hormone (FSH), and serotonin (5-HT)) between the two groups before and after treatment.Results:After treatment, the FSH level, HAMD, CES-D, sleep quality scores, and total scores in the observation group were significantly lower than those in the control group, while the levels of 5-HT and E2 were significantly higher than those in the control group (P<0.05).Conclusion:The clinical effect of rTMS combined with venlafaxine for female patients with menopause and depression is definite, and it is worth clinical application.
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| 关键词 |
关键词：重复经颅磁刺激；文法拉辛；更年期；抑郁；睡眠质量
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| KeyWord |
Key words：Repetitive transcranial magnetic stimulation; Venfarasin; the menopause; Depression; Sleep quality
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| 基金项目 |
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| 页码 |
1108-1111 |
陶颖*.
重复经颅磁刺激联合文拉法辛对更年期伴抑郁女性睡眠质量和性激素水平的影响 [J].
国际精神病学杂志.
2023; 50; (5).
1108 - 1111.