Journal of International Psychiatry

Objective: To explore the effects of scientific aerobic exercise rehabilitation therapy on cognitive function and levels of serum inflammatory factors and miR-129-5p in patients with Alzheimer’ s disease (AD). Methods: Eighty-two patients with AD admitted to the hospital from February 2021 to February 2022 were selected and randomly divided into control group (n=41) and observation group (n=41) by the single-double ball method. The control group was given routine health education while the observation group was given scientific aerobic exercise rehabilitation therapy. The cognitive function, mental state, serum inflammatory factors, miR-129-5p level and quality of life were compared between the two groups before therapy and after 2 months of therapy. Results: After 2 months of therapy, the MMSE score, miR-129-5p level, ADCS-ADL score and QOL-AD score of the two groups were enhanced compared with those before therapy, and the scores and level in observation group were higher than those in control group (all P<0.05). The ADAS-cog score, NPI score and levels of IL-6, IL-1β and TNF-α were reduced compared to before therapy, and the scores and levels in observation group were lower compared with those in control group (all P<0.05). Conclusion: Scientific aerobic exercise rehabilitation therapy can improve the cognitive function and mental state, reduce the levels of serum inflammatory factors, and enhance the level of miR-129-5p and quality of life of patients with AD.

Aerobic exercise; Alzheimer’ s disease; Cognitive function; Inflammatory factors; miR-129-5p