Journal of International Psychiatry

Objective: To explore the relationship between serum cysteine level and cognitive function in patients with schizophrenia. Methods: 60 schizophrenics and 60 healthy controls matched with age, sex and education were recruited. Serum cysteine level and plasma metabolic parameters were measured. The cognitive function of participants was assessed by the neuropsychological state scale (RBANS). Results: The level of serum cysteine in the patient group was significantly higher than that in the control group (P<0.001). Serum cysteine level and immediate memory in patients (β= 0.306; P=0.017), visual span (β= 0.287; P=0.026) and delayed memory (β= 0.277; P=0.025), but the healthy control group did not have these findings (P>0.05). Conclusion: This study further proves that oxidative stress may participate in the pathogenesis of schizophrenia, and the supplementation of cysteine may improve the cognitive level of schizophrenics. Objective: To explore the relationship between serum cysteine level and cognitive function in patients with schizophrenia. Methods: 60 schizophrenics and 60 healthy controls matched with age, sex and education were recruited. Serum cysteine level and plasma metabolic parameters were measured. The cognitive function of participants was assessed by the neuropsychological state scale (RBANS). Results: The level of serum cysteine in the patient group was significantly higher than that in the control group (P<0.001). Serum cysteine level and immediate memory in patients (β= 0.306; P=0.017), visual span (β= 0.287; P=0.026) and delayed memory (β= 0.277; P=0.025), but the healthy control group did not have these findings (P>0.05). Conclusion: This study further proves that oxidative stress may participate in the pathogenesis of schizophrenia, and the supplementation of cysteine may improve the cognitive level of schizophrenics.

schizophrenia; Cysteine; Cognitive function; Metabolic syndrome