| Abstract |
[Abstract] Objective To investigate the effects of commonly used medications for schizophrenia on patients electrocardiograms. Methods One hundred and twenty patients with schizophrenia from January 2019 to June 2022 were selected as observation subjects. They were grouped according to different antipsychotic drugs, i.e., risperidone group (n=42), quetiapine group (n=35), and clozapine group (n=43), and the treatment course was 6 months in all cases. The levels of lactate dehydrogenase (LDH), creatine kinase isoenzyme (CK-MB), and creatine kinase (CK) were compared before and after treatment. The occurrence of electrocardiographic abnormalities during the treatment period was recorded. Results The differences in serum LDH, CK-MB and CK levels were not statistically significant in all three groups before treatment (P>0.05). After treatment, all three groups were significantly higher than before treatment (P<0.05). However, there was no statistically significant difference between the three groups after treatment (P>0.05). The incidence of ST-T changes and tachycardia was significantly higher in the clozapine group than in the risperidone and quetiapine groups (P<0.05). There was no statistically significant difference in the incidence of bradycardia, sinus conduction block, sinus arrhythmia, and QT interval prolongation among the three groups (P>0.05). Conclusion Risperidone, quetiapine, and clozapine for schizophrenia all produce some cardiotoxicity and cause ECG abnormalities, but clozapine can cause more ST-T changes and tachycardia to occur.
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