Journal of International Psychiatry

[Abstract] Objective To explore the characteristics of focal characteristics of lacunar cerebral infarction (LI) with cognitive impairment. Methods A total of 100 patients with LI from January 2021 to January 2022 were selected as the study subjects. The patients combined cognitive function were assessed, and they were set as the cognitive impairment group and the non-cognitive impairment group. The MRI features of the two groups, such as general information，the number of symptoms, whether it is multiple lesions, the distribution and the location of the lesions were compared. Results There were 34 cases of cognitive impairment in 100 LI patients, 85 lesions in the cognitive impairment group and 114 lesions in the non-cognitive impairment group. The average number of lesions in the cognitive impairment group was significantly higher than that in the non-cognitive impairment group (P<0.05). The age and course of disease in the cognitive impairment group were significantly higher than those in the control group (P<0.05), but there was no significant difference in gender and educational level between the two groups (P>0.05).The detection rate of multiple lesions and left lesions in cognitive impairment group was significantly higher than that in non-cognitive impairment group, and the detection rate of right lesions was lower than that in non-cognitive impairment group (P<0.05). There was no significant difference in the detection rate of bilateral lesions (P>0.05). The detection rate of thalamus, frontal lobe and basal ganglia lesions in cognitive impairment group was higher than that in non-cognitive impairment group, while the detection rate of temporal lobe and thalamus lesions was lower than that in non-cognitive impairment group (P<0.05). There was no significant difference in the detection rate of infratentorial lesions (P>0.05). Conclusion The rate of LI combined with cognitive impairment is high. MRI imaging shows that the number of lesions, left brain lesions, and lesions involving the thalamus, frontal lobe, basal ganglia, etc. may be more likely to cause cognitive impairment.

Key words Lacunar Cerebral Infarction; Cognitive Impairment; Magnetic Resonance Imaging